![]() ![]() Quantitative analysis of the EEG frequency pattern from the depth of the brain succeeded in discrimination of drug effects according to their known clinical indication ( Dimpfel and Schober, 2003). ![]() Data from 14 synthetic drugs – tested earlier and representative for different clinical indications – were taken for construction of discriminant functions showing the projection of the frequency patterns in a six-dimensional graph. After frequency analysis (Fast Fourier Transformation) electric power was calculated for 6 ranges (delta, theta, alpha1, alpha2, beta1 and beta2). Stereotactic implantation of four semi-microelectrodes into frontal cortex, hippocampus, striatum and reticular formation of rats allowed continuous wireless monitoring of field potentials (EEG) before and after drug intake. A more holistic approach using a neurophysiological technique has been developed earlier in order to characterise synthetic drugs. Due to manifold possibly active ingredients biochemical approaches are difficult. Usually, a number of different animal tests have to be performed in order to find a potential clinical use. Herbal extracts targeting at the brain remain a continuous challenge to pharmacology. ![]()
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January 2023
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